Bridging the gap: 150μm resolution whole brain ex-vivo imaging at 7T with RF shimming

作者：Daniel S. Papp, Matthias Weigel, Mark Rekecki, Hadrien van Loo, Martin Cseh, Adrian Szum, Donggyun Park, Kelvin Chow, Tony Jimenez-Beristain, Zsolt Geretovszky, László Székely, Gonçalo Castelo‐Branco, Cristina Granziera, Tobias Granberg, Russell Ouellette · 发表于：Proceedings on CD-ROM - International Society for Magnetic Resonance in Medicine. Scientific Meeting and Exhibition/Proceedings of the International Society for Magnetic Resonance in Medicine, Scientific Meeting and Exhibition · 年份：2025 · DOI：10.58530/2025/4386 · 研究领域：Advanced MRI Techniques and Applications、Medical Imaging Techniques and Applications、Atomic and Subatomic Physics Research

Motivation: To demonstrate that ultra-high resolution whole brain MRI acquired at ultra-high field (7T) can be used to acquire mesoscale voxel sizes in ex-vivo samples, using commercially available hardware. Goal(s): To evaluate the impact of RF-shimming methods on image quality in mesoscale MRI, and to acquire ex-vivo imaging with sufficient resolution and SNR to investigate mesoscale pathology. Approach: At 150μm isotropic resolution, RF shimming approaches were compared for their SNR and CoV. Subsequently, high-SNR ex-vivo scanning was achieved by averaging and denoising, and used for neuroradiological reading. Results: Ultra-high resolution MRI enabled the detection and delineation of fine lesions and mesoscale anatomical structures. Impact: Using commercial hardware and overnight scan times, ultra-high resolution MRI at 150μm isotropic voxel size can be acquired with sufficient SNR and image quality to detect and differentiate mesoscale structures