Evaluation of nanodosimetric quantities for ion radiotherapy treatment planning based on the degree of association of survival with cluster dose

作者：Ramón Ortiz, José Ramos‐Méndez, Jian‐Hua Mao, R. Schulte, Bruce Faddegon · 发表于：Physics in Medicine and Biology · 年份：2025 · DOI：10.1088/1361-6560/ae07a3 · 被引用次数：4 · 研究领域：Machine Learning in Materials Science、Advanced X-ray and CT Imaging、Advanced Semiconductor Detectors and Materials

Abstract Objective. To demonstrate potential for a close association between cell survival and cluster dose for ionization parameters ( I p ), and to investigate the means to quantify the degree of this association when calculating cluster dose using these nanodosimetric quantities. Approach. The definitions of I p considered were the number of clusters of k or more ionizations per unit track length { C k , k = 1,…10}. For this I p definition, cluster dose is the number of clusters of k or more ionizations per unit mass. Three sets of published cell survival data, covering a range of clinically relevant particle types and energies, normal and tumor human cells, and aerobic and hypoxic conditions, were used to assess these I p . Values of C k were previously calculated for this survival data and evaluated for their application in treatment planning. New to this study, the dependence of cell survival on cluster dose, calculated as local fluence times the mean mass I p , was used. The degree of association of cell survival with cluster dose was quantified using three statistical methods: the moving window method, the residuals of linear quadratic fit, and the Bayesian information criteria. Results. all three methods identified C 5 as the most closely associated with cell survival under aerobic conditions, and C 7 under hypoxic conditions, consistent with visual observations. Remarkably, C k preferred for their close association with cell survival for different particle types hav...