Outcomes of transoral endoscopic thyroidectomy vestibular approach versus endoscopic thyroidectomy via areola approach in the treatment of thyroid carcinoma: a meta-analysis

作者：Junjun Wu, Zhi Xiao, Weiming Liang, Xiaojian Wang, Xinyi Liang, Shan Yin, Yali Yang, Jieru Quan, Zongyong Li, Chen Hu, Ping Wei · 发表于：Frontiers in Oncology · 年份：2025 · DOI：10.3389/fonc.2025.1606389 · 被引用次数：4 · 研究领域：Thyroid and Parathyroid Surgery、Thyroid Cancer Diagnosis and Treatment、Head and Neck Anomalies

Introduction: This meta-analysis was designed to compare the outcomes of transoral endoscopic thyroidectomy vestibular approach (TOETVA) versus endoscopic thyroidectomy via the areola approach (ETAA) for thyroid carcinoma. Materials and methods: Five databases (PubMed, Embase, Web of Science, Cochrane Library, and Scopus) were systematically searched for studies comparing endoscopic thyroidectomy via TOETVA versus ETAA in patients with thyroid carcinoma. The search was conducted from the databases' establishment to May 31, 2025. Operative time, intraoperative blood loss, number of central lymph node dissections, postoperative drainage volume, length of hospital stay, postoperative infection, hypoparathyroidism, perioperative recurrent laryngeal nerve injury, complication, hypocalcemia, subcutaneous ecchymosis, cough, trachyphonia, postoperative parathyroid hormone (PTH), postoperative blood calcium, pain score of Visual Analogue Scale (VAS), swallowing discomfort, hematoma, central lymph node dissection time, and satisfaction with cosmetic effects were subjected to meta-analyses. Results: A total of 15 studies were included in the meta-analysis. The meta-analysis included a group of 1,961 patients diagnosed with thyroid carcinoma. Within this cohort, 777 patients underwent endoscopic thyroidectomy via TOETVA, while 1,184 patients underwent endoscopic thyroidectomy via ETAA. Compared with ETAA, TOETVA yielded lower intraoperative bleeding volume [weighted mean difference (WMD ...