Atherogenic ApoB-dyslipidemia, atherosclerotic cardiovascular disease, cardiac dysfunction and remodeling in high-risk young women with and without polycystic ovary syndrome: A pilot study

作者：Xiaoying Wu, Mich Wilke, Jesse Batara, Spencer D. Proctor, Melanie Cree‐Green, Mahua Ghosh, Paolo Raggi, Jonathan Windram, Harald Becher, Donna F. Vine · 发表于：Frontiers in Endocrinology · 年份：2025 · DOI：10.3389/fendo.2025.1520922 · 被引用次数：5 · 研究领域：Ovarian function and disorders、Cardiovascular Disease and Adiposity、Lipid metabolism and disorders

Introduction: Polycystic ovary syndrome (PCOS) is associated with increased cardiometabolic risk in young women of reproductive age. There are limited studies on atherogenic dyslipidemia, inclusive of triglycerides (TG), Apolipoprotein (apo) B-lipoproteins and remnant-cholesterol (C), atherosclerotic cardiovascular disease (ACVD), cardiac function and remodeling in young women with and without PCOS. The aim of this pilot study was to investigate the relationship of atherogenic dyslipidemia and other cardiometabolic risk factors with ACVD, cardiac function-remodeling in high-risk young overweight-obese PCOS women compared to non-PCOS and healthy-weight controls. Methods: ) were matched for age and BMI, and by age with healthy-weight non-PCOS controls. PCOS diagnosis was based on Rotterdam criteria. Fasting lipids and non-fasting plasma lipid assessment included TG, remnant-C, total ApoB, ApoB48 and ApoB100. Carotid intimal-medial thickness (cIMT) and carotid plaque height were assessed, and cardiac function and remodeling were measured by 2-D ultrasound and 3D-echocardiography. Results: PCOS (n=48) and non-PCOS control overweight-obese age-BMI matched groups (n=19) were shown to have significantly higher fasting and non-fasting lipids including TG, remnant-C, total ApoB and ApoB48, compared to healthy-weight non-PCOS controls (n=10). PCOS and non-PCOS control overweight-obese groups had significantly higher SBP, DBP, cIMT and evidence of cardiac dysfunction and remodeling, wit...