Evidence summary: Prehabilitation strategies for patients with primary liver cancer

作者：Jinyi Tu, Yan Shen, Yun Chen, Yanshan Zhang, Sijia Zhou, Weixiang Luo, Haiyan Zhang · 发表于：Asia-Pacific Journal of Oncology Nursing · 年份：2025 · DOI：10.1016/j.apjon.2025.100783 · 被引用次数：4 · 研究领域：Cancer survivorship and care、Nutrition and Health in Aging、Childhood Cancer Survivors' Quality of Life

Objective: To synthesise and appraise current evidence on prehabilitation strategies for patients with primary liver cancer. Methods: Using the PIPOST framework, we formulated clinical questions and defined eligibility criteria. Guided by the "5S" evidence hierarchy, a comprehensive search was conducted across 20 sources-including clinical decision systems, guideline repositories, bibliographic databases, and professional society websites-from inception to 1 December 2024. Two independent reviewers screened and appraised eligible studies, and evidence synthesis was limited to those meeting predefined quality standards. Nine experts evaluated the evidence through a structured consensus process based on the FAME framework to determine recommendation grades. Results: Twenty studies were included: 1 clinical decision tool, 5 guidelines, 5 systematic reviews, 5 expert consensuses, 3 evidence summaries, and 1 randomised controlled trial. A total of 36 evidence statements were extracted and categorised into six domains: prehabilitation candidates, timing of prehabilitation, nutritional optimisation, physical exercise, psychological support, and health education. Although part of the evidence originated from non-liver cancer populations, extrapolation was considered reasonable due to shared pathophysiological risks across major abdominal surgeries. Of these, 34 evidence statements received strong recommendations after expert appraisal. Conclusions: This study consolidates practical, ...