DLGAP5 Promotes Acute Liver Injury via Hepatocyte Pyroptosis-Driven Macrophage Metabolic Reprogramming and M1 Polarization

作者：Xianzhi Liu, Zhiyuan Chen, Junxin Lin, Yifan Lian, Wenxuan Gan, Huajie Liu, Xing Huang, Jiaxin Mei, Tianrong Ma, Zhi Lü, Wei Zeng, Yihang Gong, Shuai Chen, Weiling He · 发表于：International Journal of Biological Sciences · 年份：2025 · DOI：10.7150/ijbs.118024 · 被引用次数：10 · 研究领域：Mitochondrial Function and Pathology、Liver Disease Diagnosis and Treatment、Endoplasmic Reticulum Stress and Disease

deficiency alleviated ALI by suppressing hepatocyte pyroptosis and blocking communication between macrophages and hepatocytes. Our findings indicate the potential mechanisms of ALI from an intercellular communication perspective, and targeted-inhibition of DLGAP5 and -blockade of hepatocyte-macrophage interaction provide promising strategies for ALI treatment.