Comprehensive analytical approach identifies a subtype of CTCF+ tumor-associated neutrophils associated with CRC development and as a biomarker for immunotherapy

作者：Jie-pin Li, Yuan‐jie Liu, Yi Zhang, Qianwen Ye, Xu Guo, Jin-Chen Chong, Yi Yin, Zhimin Li, Shuangshuang Wang, Jin‐Yong Zhou, Jun Qian, Shenlin Liu, Xi Zou, Yu-gen Chen · 发表于：International Journal of Biological Sciences · 年份：2025 · DOI：10.7150/ijbs.111529 · 被引用次数：4 · 研究领域：Immune cells in cancer、S100 Proteins and Annexins、Neutrophil, Myeloperoxidase and Oxidative Mechanisms

CTCF+ TANs represent a novel TAN subtype that drives CRC progression and immunosuppression via the CTCF-MIEN1-IL-1β axis. These findings highlight the potential of targeting CTCF+ TANs to overcome immunotherapy resistance and improve patient outcomes.