The China Brain Multi-omics Atlas Project (CBMAP)

作者：Dan Zhou, Yuan Zhou, Zeyu Sun, Feiyang Ji, Dandan Zhang, Quan Wang, Yijun Ruan, Yongcheng Wang, Yimin Zhu, Xiaohui Sun, Mulin Jun Li, Changzheng Yuan, Kefu Liu, Lingyun Sun, Wenli Zhai, Jiayao Fan, Keqing Zhu, Wenying Qiu, Xiao‐Xin Yan, Chao Ma, Yi Shen, Ai‐Min Bao, Weihua Yue, Yongyong Shi, Chao Chen, Jian Yang, Shumin Duan, Jing Zhang · 发表于：Molecular Psychiatry · 年份：2025 · DOI：10.1038/s41380-025-03250-3 · 被引用次数：4 · 研究领域：Bioinformatics and Genomic Networks、RNA modifications and cancer、Metabolomics and Mass Spectrometry Studies

The China Brain Multi-omics Atlas Project (CBMAP) aims to generate a comprehensive molecular reference map of over 1000 human brains (Phase I), spanning a broad age range and multiple regions in China, to address the underrepresentation of East Asian populations in brain research. By integrating genome, epigenome, transcriptome, proteome (including multiple post-translational modifications), and metabolome data, CBMAP is set to provide a rich and invaluable resource for investigating the molecular underpinnings of aging-related brain phenotypes and neuropsychiatric disorders. Leveraging high-throughput omics data and advanced technologies, such as spatial transcriptomics, proteomics, and single-nucleus 3D chromatin structure analysis, this atlas will serve as a crucial resource for the brain science community, illuminating disease mechanisms and enhancing the utility of data from genome-wide association studies (GWAS). CBMAP is also poised to accelerate drug discovery and precision medicine for brain disorders.