Association of Systemic Inflammatory Biomarkers (NLR, MLR, PLR, SII, SIRI) with Preeclampsia-Related Kidney Injury: A Retrospective Observational Study

作者：Lina Gao, Yan Dong, Xiaohui Liu, Chen De, Hong Guo, Jian Liu · 发表于：Journal of Inflammation Research · 年份：2025 · DOI：10.2147/jir.s542136 · 被引用次数：5 · 研究领域：Pregnancy and preeclampsia studies、Inflammatory Biomarkers in Disease Prognosis、Acute Kidney Injury Research

Background: Approximately 7– 13% of pregnant women with preeclampsia (PE) develop acute kidney injury (AKI), which is one of the most serious complications of PE and is linked to long-term chronic kidney disease. This retrospective observational study investigated the association between inflammation indices and PE-related acute kidney injury (PE-AKI). Methods: This retrospective study analyzed 4071 PE patients admitted between 2013 and 2023. Inflammatory indices, including neutrophil-to-lymphocyte ratio (NLR), monocyte-to-lymphocyte ratio (MLR), platelet-to-lymphocyte ratio (PLR), systemic immune-inflammation index (SII), and systemic inflammation response index (SIRI), were derived from complete blood counts. Multivariate logistic regression assessed associations with PE-AKI risk, with nonlinear relationships characterized using restricted cubic spline models. Results: Among 4071 patients with PE, 290 (7.13%) developed AKI. Multivariate analysis (Model 3) revealed significant positive associations between log 2 -transformed inflammatory indices and PE-AKI risk, with the highest odds ratios observed for MLR (OR = 6.02, 95% CI: 4.68– 7.73; P < 0.0001) and NLR (OR = 3.93, 95% CI: 3.09– 5.01; P < 0.0001). MLR demonstrated the strongest independent correlation with PE-AKI (highest tertile OR = 7.24, 95% CI: 4.75– 11.02), followed by SIRI (OR = 5.78, 95% CI: 3.89– 8.59). All indices (NLR, MLR, PLR, SII, SIRI) exhibited linear dose-response relationships with PE-AKI risk ( P -over...