Performance of flash continuous glucose monitoring and glycemic marker correlations in Chinese pregnant women with non-type 1 diabetes

作者：Ling Lyu, Yiling Huang, Yu Huang, Zeyu Wu, Fan Ping, Yuxiu Li · 发表于：World Journal of Diabetes · 年份：2025 · DOI：10.4239/wjd.v16.i8.106967 · 被引用次数：2 · 研究领域：Diabetes Management and Research、Gestational Diabetes Research and Management、Hyperglycemia and glycemic control in critically ill and hospitalized patients

BACKGROUND: Maternal diabetes significantly increases the risk of adverse maternal and neonatal outcomes. Traditional self-monitoring of blood glucose is often invasive and limited in its ability to capture glycemic variability. Flash continuous glucose monitoring (FCGM) offers a promising alternative; however, its reliability and correlation with biochemical markers such as hemoglobin A1c (HbA1c) and glycated albumin (GA) in pregnant women with gestational diabetes mellitus (GDM) and type 2 diabetes mellitus (T2DM) remain underexplored. AIM: To evaluate the performance of the FreeStyle Libre H FCGM against plasma glucose and its correlations with HbA1c and GA. METHODS: This prospective observational study involved 152 pregnant women with GDM or T2DM, with intermittent collection of venous plasma glucose, HbA1c, GA, and concurrent FCGM data at regular intervals at a single center. Relationships were evaluated using restricted cubic spline and mixed-effects models. Receiver operating characteristic curve analysis was performed to compare the ability of HbA1c and GA to detect suboptimal glycemic control. RESULTS: Analysis of 507 FCGM-plasma glucose pairs revealed an overall mean absolute relative difference of 7.96%. Mean absolute relative differences were 9.22%, 7.75%, and 4.15% for low (3.5-4.4 mmol/L), medium (4.5-7.8 mmol/L), and high (7.9-13 mmol/L) glucose levels, respectively. Most values fell within zone A or zone B on the Clarke and Parkes Error Grids. Bland-Altman ana...