Curcumin suppresses colorectal cancer by inhibiting TRIM2 and mTOR signaling

作者：Hang Yu, Haikuo Wu, Qianhui Zhao, Ruitao Zhao, Jian Liu, Zhiyuan Yang, Song Wang, Yudong Li · 发表于：Translational Oncology · 年份：2025 · DOI：10.1016/j.tranon.2025.102517 · 被引用次数：6 · 研究领域：interferon and immune responses、Curcumin's Biomedical Applications、Calpain Protease Function and Regulation

• Curcumin demonstrates potent inhibitory effects on the expression of the Tripartite motif-containing protein 2(TRIM2) gene in colorectal cancer cells. • By suppressing TRIM2 expression, curcumin significantly disrupts the Mammalian Target of Rapamycin (mTOR) signalling pathway. • Ccurcumin effectively suppresses colorectal cancer cell proliferation and induces cell cycle arrest, ultimately leading to a significant reduction in tumour growth. • Curcumin exhibits a favourable safety profile, making it a promising therapeutic agent for colorectal cancer treatment. • The findings highlight the potential of curcumin as a novel and targeted agent for inhibiting colorectal cancer development by modulating TRIM2 expression and the mTOR signalling pathway. Curcumin, a natural polyphenol, exhibits potent anti-cancer activities, but its underlying molecular mechanisms in colorectal cancer (CRC) are not fully elucidated. Here, we investigated t whether curcumin suppresses CRC by targeting tripartite motif-containing protein 2 (TRIM2) and its downstream the Mammalian Target of Rapamycin (mTOR) signaling pathway. We initially performed a whole-genome expression profile chip to examine gene alterations following curcumin administration. Our results demonstrate that curcumin effectively decreased the expression of TRIM2 in CRC cells. Furthermore, PCR and immunohistochemical (IHC) staining of tumour samples confirmed the elevated expression of TRIM2 in CRC cells and CRC tumour samples. Addi...