EDA Complex Initiated C–H Difluoroalkylation of Quinoxalin-2(1 H )-ones with Fluoroalkyl Bromides

作者：Huanhuan Cui, Chunyu Hu, Xiulin Qiao, Tiesheng Shi, Chao Chen, Wei Wei, Zu‐Li Wang, Zhuoming Ma · 发表于：The Journal of Organic Chemistry · 年份：2025 · DOI：10.1021/acs.joc.5c01666 · 被引用次数：8 · 研究领域：Fluorine in Organic Chemistry、Radical Photochemical Reactions、Synthesis and Biological Evaluation

An efficient visible-light-induced EDA strategy has been developed for constructing 3-difluoroalkylated quinoxalin-2(1 H )-ones through the C–H difluoroalkylation of quinoxalin-2(1 H )-ones with fluoroalkyl bromides. This transformation could provide a series of 3-difluoroalkylated quinoxalin-2(1 H )-ones in moderate to good yields under mild and metal-free conditions. Mechanistic studies revealed that the formation of the EDA complex between fluoroalkyl bromide and TMEDA was essential to initiate this transformation.