Dual-Copper-Catalyzed Enantioselective Decarboxylative [2 + 3] Cycloaddition of Ethynyl Cyclic Carbamates/Carbonates with 4-Hydroxycoumarins

作者：Wen‐Ya Lu, Yong You, Zhen‐Hua Wang, Lei Yang, Jian‐Qiang Zhao, Ming‐Qiang Zhou, Jun‐Qing Yin, Wei‐Cheng Yuan · 发表于：Organic Letters · 年份：2025 · DOI：10.1021/acs.orglett.5c03409 · 被引用次数：4 · 研究领域：Catalytic C–H Functionalization Methods、Asymmetric Synthesis and Catalysis、Microbial Natural Products and Biosynthesis

A dual-copper-catalyzed enantioselective decarboxylative [2 + 3] cycloaddition of ethynyl cyclic carbamates/carbonates with 4-hydroxycoumarins and 4-hydroxyl pyrones was developed. This reaction provides an efficient method for accessing a wide range of optically pure dihydrofuro[3,2- c ]coumarin derivatives in high yields with good to excellent enantioselectivities (61 examples, up to 99% yield and 99% ee). Notably, the ethynyl cyclic carbamates/carbonates were used as unconventional bis-electrophilic 2C (Cγ-Cβ) synthetic units for an enantioselective [2 + 3] cycloaddition reaction.