Effect modification of long-term air pollution exposure on the association of physical activity with COPD hospitalization: a prospective cohort study of 0.5 million Chinese adults

作者：Xi Xia, Cong Liu, Yue Niu, Xia Meng, Neil Wright, Christiana Kartsonaki, Yiping Chen, Ling Yang, Huaidong Du, Canqing Yu, Dianjianyi Sun, Jun Lv, Junshi Chen, Liming Li, Maxim Barnard, Kai Kang, Shaowei Wu, Ka Hung Chan, Hubert Lam, Haidong Kan, Zhengming Chen · 发表于：The Lancet Regional Health - Western Pacific · 年份：2025 · DOI：10.1016/j.lanwpc.2025.101676 · 被引用次数：1 · 研究领域：Chronic Obstructive Pulmonary Disease (COPD) Research、Air Quality and Health Impacts、Cardiovascular Health and Risk Factors

Background: Little is known about how long-term ambient air pollution exposure modifies the potential benefits of physical activity against chronic obstructive pulmonary disease (COPD). We aimed to examine the interaction between ambient air pollution and physical activity in relation to risk of COPD hospitalization. Methods: ), respectively, using multivariable Cox regression. Findings: ). The effect modification strengthened when stratifying participants by higher cut-offs of air pollution exposure. Interpretation: Long-term exposure to ambient air pollution is associated with attenuation of the potential benefits of physical activity against COPD in Chinese adults. Funding: Sino-British Fellowship Trust, National Key Research and Development Program of China, Kadoorie Charitable Foundation, Wellcome, Noncommunicable Chronic Diseases-National Science and Technology Major Project, National Natural Science Foundation of China, UK Medical Research Council, Cancer Research UK, British Heart Foundation.