PathoBase: an integrated One Health approach for zoonotic pathogen genomics analysis

作者：Shengkai Li, Jie Rong, Ling Zhong, Guilai Jiang, Xiao Liu, Yi Ren, Zhemin Zhou, Heng Li · 发表于：One Health Advances · 年份：2025 · DOI：10.1186/s44280-025-00087-x · 被引用次数：1 · 研究领域：Zoonotic diseases and public health、Microbial infections and disease research、Bacteriophages and microbial interactions

Abstract The rapid identification and genomic analysis of zoonotic pathogens are essential for effective disease surveillance and outbreak response. PathoBase, an advanced computational platform developed for researchers, addresses regional challenges in pathogen genomics by offering a comprehensive, efficient, and freely accessible tool for genomic data analysis building on core-genome multilocus sequence typing. The platform currently hosts 132 bacterial strains, including Acinetobacter ( n = 112) and Staphylococcus ( n = 20), with additional genera under development. The key objectives of PathoBase include establishing a zoonotic pathogen repository for regional surveillance, developing rapid source-tracing technologies to enhance outbreak control, and promoting interdisciplinary collaboration to strengthen public health security.