Cyclin-dependent kinase inhibitor 1A mediates mouse line- and fate-dependent cellular responses in Cx3cr1-Cre genetic tools

作者：Ayato Yamasaki, Hayato Shintaku, Akihito Harada, Kazumitsu Maehara, Kaori Tanaka, Mai Saeki, Minako Ito, Hiroyuki Konishi, Makoto Tsuda, Marco Prinz, Yusuke Kishi, Yasuyuki Ohkawa, Shota Yamamoto, Takahiro Masuda · 发表于：Cell Reports · 年份：2025 · DOI：10.1016/j.celrep.2025.116267 · 被引用次数：2 · 研究领域：Neuroinflammation and Neurodegeneration Mechanisms、interferon and immune responses、MicroRNA in disease regulation

microglia are mitigated by a functional inhibition of CDKN1A. Together, these findings underscore the significance of mouse line-specific phenomena that alter microglial outcomes in a CDKN1A-dependent manner.