3D-Printed Array Helical Monolithic Column Chip with Hierarchical Porous Structure for High-Throughput ICP-MS Analysis of Trace Rare-Earth Elements

作者：Cheng Lei, Man He, Beibei Chen, Bin Hu · 发表于：Analytical Chemistry · 年份：2025 · DOI：10.1021/acs.analchem.5c03633 · 被引用次数：3 · 研究领域：Innovative Microfluidic and Catalytic Techniques Innovation、Pickering emulsions and particle stabilization、Covalent Organic Framework Applications

Three-dimensional printing (3DP) technology enables the flexible fabrication of integrated monolithic microextraction chips for high-throughput sample pretreatment. Meanwhile, the extraction performance of 3DP-based channels is largely limited by printer resolution and the commercially available printing materials. In this work, a 3DP array monolithic microextraction chip (AMC) was fabricated by integrating 26-array helical monolithic microextraction channels for sample pretreatment and 52-array gas valves for fluid control. 3DP with a liquid crystal display, switching between flexible and rigid resins, was employed to fabricate fluid-control valves and helical microchannels, respectively. Hierarchical porous monolithic column in microchannels was obtained by in-situ polymerization of a high internal phase Pickering emulsion, with carbonyl-containing covalent organic frameworks (COFs) employed for the first time as both emulsifier and stabilizer. The amphiphilic COFs with balanced hydrophilic carbonyl groups and hydrophobic benzene rings was selected to facilitate the emulsion template formation for the monolith’s porous structure while providing effective functional sites for adsorption. The helical shape and internal hierarchical porous structure of the monolithic column both help to improve mass transfer during adsorption and desorption. Based on the above facts, a method by online coupling 3DP-AMC with inductively coupled plasma-mass spectrometry (ICP-MS) detection was de...