Trends in the incidence of lung cancer in never smokers in Eastern China: a retrospective population-based cohort study using regional electronic health records

作者：Xiao Ge, Xing Liu, Wanghong Xu, Yexiang Sun, Hongbo Lin, Peng Shen, Haiquan Chen, Na He · 发表于：BMJ Open · 年份：2025 · DOI：10.1136/bmjopen-2025-104941 · 被引用次数：3 · 研究领域：Lung Cancer Diagnosis and Treatment、Global Cancer Incidence and Screening、Lung Cancer Treatments and Mutations

OBJECTIVES: Although lung cancer in never smokers (LCNSs) accounts for an estimated 25% of all lung cancer cases, the temporal trends in LCNS incidence and its broader epidemiological patterns remain poorly understood. Our study examines the temporal trends in LCNS incidence and analyses key epidemiological characteristics, specifically, the trends in mortality rates, survival rates and changes in age at onset to illuminate the reasons for temporal trends in LCNS incidence. DESIGN: Retrospective population-based cohort study. SETTING: Regional electronic health record (EHR) database linked to the cancer registry in eastern China. PARTICIPANTS: A total of 1 080 317 adults who have never smoked were included, among whom 4061 incident lung cancer cases were identified between 1 January 2009 and 31 December 2020. PRIMARY AND SECONDARY OUTCOME MEASURES: The temporal trends in LCNS incidence in a large population-based dynamic cohort were estimated, overall and separately by sex, age group and histological types. The broader epidemiological patterns of LCNS, such as trends in mortality rates, survival rates and changes in age at onset, were analysed. RESULTS: From 2009 through 2020, the incidence of LCNS among men increased significantly from 9.51 to 43.4 per 100 000 (average annual percentage change (AAPC) 10.51%; 95% CI (6.88% to 14.26%)) whereas a sharper increase was observed among women from 3.57 to 51.68 per 100 000 (AAPC 22.39%; 95% CI (18.36% to 26.55%)). The 2-year surviva...