Dose-dependent interaction of dietary vitamin B2 and E in relation to cognitive performance: a cross-sectional study of older adults

作者：Yueju Wu, Hai Zhou, Yong Cai, Wenjuan Du, Chaonian Li, Minli Sun · 发表于：Frontiers in Nutrition · 年份：2025 · DOI：10.3389/fnut.2025.1597724 · 研究领域：Antioxidant Activity and Oxidative Stress、Folate and B Vitamins Research、Vitamin K Research Studies

Background While individual associations of dietary vitamins with cognitive function have been widely studied, the combined role of vitamin B2 and E remains poorly understood. This study investigates their interactive effects on cognitive performance in older adults. Methods In this cross-sectional analysis of 2,497 participants (age ≥60 years) from NHANES 2011–2014, cognitive function was assessed using the Digit Symbol Substitution Test (DSST), with low performance defined as DSST scores <33 (lowest quartile). Dietary intake of vitamins B2 and E was derived from two 24-h recalls. Multivariable logistic regression models adjusted for sociodemographic, lifestyle, and clinical covariates examined independent and joint associations, with interaction effects quantified using product terms. Results Following comprehensive adjustment, elevated dietary intake of vitamin B2 [odds ratio (OR) = 0.74, 95% confidence interval (CI): 0.58–0.95] and vitamin E (OR = 0.73, 95% CI: 0.56–0.94) was independently associated with diminished odds of low cognitive function. A significant multiplicative interaction was observed (OR = 1.15, 95% CI: 1.05–1.26; p < 0.05). Marginal effect analyses revealed synergistic benefits between vitamins B2 and E at vitamin E intakes <18 mg/day, whereas antagonistic interaction emerged beyond this threshold. Furthermore, stratified analyses identified the strongest protective effects in the high-B2 + low-E group (OR = 0.56, 95% CI: 0.32–0.98) ...