Drop-printing with dynamic stress release for conformal wrap of bioelectronic interfaces

作者：An Li, Wenjianlong Zhou, Huizeng Li, Wei Fang, Yifei Luo, Zheng Li, Qingrong Zhang, Quan Liu, Qin Xu, Luanluan Xue, Kaixuan Li, Renxuan Yuan, Wan‐Ling Liu, Wang Jia, Xiaodong Chen, Yanlin Song · 发表于：Science · 年份：2025 · DOI：10.1126/science.adw6854 · 被引用次数：19 · 研究领域：Advanced Sensor and Energy Harvesting Materials、Neuroscience and Neural Engineering、Advanced Materials and Mechanics

Bioelectronic interfaces demonstrate promising applications in health monitoring, medical treatment, and augmented reality. However, conformally wrapping these film devices onto three-dimensional surfaces often leads to stress-induced damage. We propose a "drop-printing" strategy that enables damage-free film transfer using a droplet. The droplet acts as a lubricating layer between the film and the target surface, facilitating local sliding during shape-adaptive deformation. This mechanism prevents in-plane film stretching and reduces stress concentration. Even nonstretchable and fragile films can be intactly and accurately wrapped onto delicate surfaces, such as microscale microorganisms and optical fibers. Two-micrometer-thick silicon films, without any stretchable engineering, can form conformal neural-electronic interfaces by being drop-printed on nerves and brain tissue. The interfaces achieve light-controlled in vivo neuromodulation with high spatiotemporal resolution.