Global, regional, and national burden of ovarian cancer, 1990–2021, and projections to 2050: a cross-sectional analysis of the Global Burden of Disease Study 2021

作者：Weimin Xie, S. Tang, Rong Tang, Liping Li, Xiaohang Liu · 发表于：International Journal of Surgery · 年份：2025 · DOI：10.1097/js9.0000000000003398 · 被引用次数：12 · 研究领域：Ovarian cancer diagnosis and treatment、Ferroptosis and cancer prognosis、PARP inhibition in cancer therapy

BACKGROUND: Ovarian cancer remains the most lethal gynecological cancer, with fewer than 50% of patients surviving more than 5 years after diagnosis. This study aimed to analyze the global epidemiological trends of ovarian cancer from 1990 to 2021 and also project its prevalence to 2050, providing insights into these evolving patterns and helping health policymakers use healthcare resources more effectively. METHODS: This study comprehensively analyzes the original data related to ovarian cancer from the Global Burden of Disease Study 2021 database, employing a variety of methods including descriptive analysis, correlation analysis, age-period-cohort analysis, decomposition analysis, predictive analysis, frontier analysis, and health inequality analysis. The aim is to explore the disease burden of ovarian cancer and its changing trends in detail. RESULTS: From 1990 to 2021, the age-standardized incidence rate (ASIR), age-standardized mortality rate (ASMR), and age-standardized disability-adjusted life year rate (ASDR) for ovarian cancer significantly increased, while the age-standardized prevalence rate (ASPR) showed a marked decline. In 2021, the ASIR of ovarian cancer was 6.71 per 100 000 population, the ASPR was 28.08 per 100 000, the ASMR was 4.06 per 100 000, and the ASDR was 115.15 per 100 000. As the Social Development Index (SDI) increased, the disease burden of ovarian cancer exhibited a trend of rising initially followed by a decline. Health inequalities between cou...