Obesity is associated with greater variability of reward signals in the nucleus accumbens

作者：Mechteld M. van den Hoek Ostende, Anne Kühnel, Monja P. Neuser, Thomas Dresler, Jennifer Svaldi, Nils B. Kroemer · 发表于：Translational Psychiatry · 年份：2026 · DOI：10.1038/s41398-026-04172-6 · 被引用次数：1 · 研究领域：Adipose Tissue and Metabolism

Abstract Background Binge eating disorder (BED) is characterized by repeated episodes of binge eating accompanied by a loss of control. Although it remains unknown which factors drive binge eating (BE) episodes, there are indications that variability in nucleus accumbens (NAcc) responses could lead to increased variability in food intake. Methods Here, we assessed whether BED is associated with higher intra-individual variability in behavioral and neuroimaging indices of reward responses. To this end, patients with BED ( n = 35, M BMI = 33.2 kg/m 2 ± 6.8), participants with subsyndromal BED ( n = 21, M BMI = 29.0 kg/m 2 ± 7.2), and individuals without symptoms of binge eating ( n = 23, M BMI = 32.3 kg/m 2 ± 6.5) completed an effort allocation task with concurrent functional magnetic resonance imaging. Results In line with our hypothesis, we found that patients with BED had higher variability in subjective wanting ratings of food ( F 34,21 =1.48, p boot = .024), but not effort exertion ( F 34 ,21 = 1.13, p boot = .30). Crucially, trial-by-trial variability in NAcc responses during the presentation of cues was associated with a higher BMI ( b =0.11, 95%CI [0.03, 0.19], BF 10 =11.1) and disinhibited eating ( b =0.19, 95%CI [0.01, 0.36], BF 10 =4.0) across groups, whereas NAcc variability was only marginally elevated in patients with BED ( b =0.12, 95%CI [−0.04, 0.29], BF 10 =1.2, P>0|data = 88%). Conclusions Our results support the idea that BMI and disinhibited eating are as...