Ruthenium-Catalyzed Intermolecular [2 + 2] Cycloaddition of Unactivated Allenes and Alkynes with Unusual Regioselectivity

作者：Chaoshen Zhang, Herman H. Y. Sung, Ian D. Williams, Yun‐Dong Wu, Jianwei Sun · 发表于：Journal of the American Chemical Society · 年份：2025 · DOI：10.1021/jacs.5c11285 · 被引用次数：9 · 研究领域：Catalytic Alkyne Reactions、Catalytic C–H Functionalization Methods、Asymmetric Hydrogenation and Catalysis

High Resolution Image Download MS PowerPoint Slide Described here is an efficient protocol for intermolecular [2 + 2] cycloaddition of unactivated and unsymmetrical allenes and alkynes with unusual regioselectivity, counterintuitively favoring the most hindered isomer. CpRu(MeCN) 3 PF 6 served as a uniquely effective catalyst, providing diverse 3-alkylidenecyclobutenes with a broad scope and good functional group compatibility. Both experiments and DFT studies provided important insights into the mechanism, particularly the unusual regioselectivity.