Ultrasound-assisted extraction of naringin from Exocarpium Citri Grandis using a novel ternary natural deep eutectic solvent based on glycerol: Process optimization using ANN-GA, extraction mechanism and biological activity

作者：Hailin Ran, Xuxiang Zhang, Jiafei Long, Zhijia Wang, Sheng‐Yi Zhuang, Xin Zhang, Yongmei Jiang, Jianyong Zhang, Wang Gang · 发表于：Ultrasonics Sonochemistry · 年份：2025 · DOI：10.1016/j.ultsonch.2025.107551 · 被引用次数：11 · 研究领域：Phytochemical compounds biological activities、Multicomponent Synthesis of Heterocycles、Natural product bioactivities and synthesis

values of 19.6 μg/mL (α-glucosidase), 2.73 mg/mL (pancreatic lipase), and 1,086 μg/mL (acetylcholinesterase). These results indicate its potential for hypoglycemic, hypolipidemic, and anti-Alzheimer's therapeutic effects. This work establishes a sustainable strategy for efficient Nar extraction, integrating green solvent technology with bioactivity assessment to advance its therapeutic potential.