Associations between endothelial inflammatory markers and cerebral small vessel disease in a community-based population

作者：Xia Zhang, Lingling Jiang, Xueli Cai, Jing Jing, Shan Li, Mengxing Wang, Suying Wang, Xuan Wang, Tiemin Wei, Yongjun Wang, Yuesong Pan, Yilong Wang · 发表于：International Journal of Stroke · 年份：2025 · DOI：10.1177/17474930251380170 · 被引用次数：4 · 研究领域：Intracerebral and Subarachnoid Hemorrhage Research、Cerebrospinal fluid and hydrocephalus、Barrier Structure and Function Studies

Background: Endothelial inflammation is involved in cerebral small vessel disease (CSVD) pathogenesis. Vascular cell adhesion molecule 1 (VCAM-1) and intercellular adhesion molecule 1 (ICAM-1) are biomarkers of endothelial inflammation. Aims: This study investigated the association of VCAM-1 and ICAM-1 with the presence of CSVD and CSVD burden. Methods: This cross-sectional study included community residents from the Polyvascular Evaluation for Cognitive Impairment and Vascular Events (PRECISE) study. Fasting venous blood was drawn to assay VCAM-1 and ICAM-1. Cognition was assessed by the Montreal Cognitive Assessment (MoCA). Cognitive impairment was defined as MoCA scores < 26. White matter hyperintensity, lacunes, cerebral microbleeds, and enlarged perivascular spaces were evaluated in a 3.0T MRI scanner. CSVD burden was rated according to the criteria of Wardlaw’s (score 0–4) and Rothwell’s (score 0–6), and classified into four grades. Presence of CSVD was defined as CSVD burden score ⩾ 1. Results: This study included 2596 participants with a mean age of 61.2 ± 6.7 years and 50.9% of males. Elevated VCAM-1 was associated with increased odds of presence of CSVD (Rothwell: odds ratio (OR) = 1.16, 95% confidence interval (CI): 1.06–1.26, P = 0.001), higher CSVD burden (Wardlaw: common OR (cOR) = 1.11, 95% CI: 1.02–1.21, P = 0.02; Rothwell: cOR = 1.16, 95% CI: 1.07–1.25, P < 0.001), and presence of cognition-impaired CSVD (Rothwell: OR = 1.15, 95% CI: 1.05–1.25, P = 0.00...