Association of life's essential 8 and genetic predisposition with the risk of osteoarthritis: a prospective cohort study

作者：Chuan Du, Tingting Zhou, Xiang Ji, Xiaofu Tang, Honghao Yang, Zheng Ma, Mingjie Kuang, Liangkai Chen, X. Li, Hongfei Wang, Chengrui Yang, Xiaomin Li, Jianyong Zhao, Yang Xia · 发表于：Frontiers in Nutrition · 年份：2025 · DOI：10.3389/fnut.2025.1642749 · 被引用次数：2 · 研究领域：Osteoarthritis Treatment and Mechanisms、Cardiovascular Health and Risk Factors、Genetic Associations and Epidemiology

Background: Osteoarthritis (OA) is a prevalent joint disorder with significant health and economic impacts. While individual cardiovascular health (CVH) factors have been linked to OA, a comprehensive understanding of how overall cardiovascular health influences OA risk is lacking. Life's Essential 8 (LE8) offers a holistic measure incorporating physical activity, body mass index, diet, sleep, blood pressure, blood sugar, lipids, and nicotine exposure. The inclusion of LE8 in OA research is crucial to better understand the broader cardiovascular health-OA association. Methods: The present study was conducted using data from the UK Biobank, which initially included more than 500,000 participants. After applying exclusion criteria, a total of 242,278 participants without hip and/or knee OA at baseline were included in the final analyses. Genetic risk scores (GRSs) for hip, knee, and hip/knee OA were derived from 70, 83, and 87 single-nucleotide polymorphisms, respectively. Restricted cubic splines (RCS) were utilized to explore the potential non-linear associations of GRSs with the risks of OA. Cox proportional hazards models were applied to assess the associations between LE8, GRSs, and the risk of OA. Both combined effect and interaction analyses were conducted to evaluate how LE8 and GRSs jointly influence OA risk. Results: During a median follow-up period of 12.12 years, 18,767 participants developed hip and/or knee OA. LE8 was found to be negatively associated with the ris...