DDX3X mutation and Epstein-Barr virus cooperate to induce R-loop-dependent oncogenesis

作者：Hua-Man Cai, Yuran Qiu, Yun Tan, Kun Cai, Shu Cheng, Huijuan Zhong, Di Fu, Haiyang Lu, Guoyu Meng, Yan Zhao, Zheng Ruan, Wenfang Wang, Min Lü, Jian Zhang, Zhu Chen, Saijuan Chen, Jie Xiong, Weili Zhao · 发表于：Cell Reports · 年份：2025 · DOI：10.1016/j.celrep.2025.116237 · 被引用次数：5 · 研究领域：Lymphoma Diagnosis and Treatment、Viral-associated cancers and disorders、RNA modifications and cancer

tumors. These findings provide a better understanding of the functional interaction of the DDX3X mutation with EBV to provoke R-loop-dependent oncogenesis, shedding light on the pathogenic mechanism of EBV and future therapeutic approaches targeting R-loops in diseases involving RNA helicase alterations.