Single‐Cell and Spatial Transcriptomic Profiling of Penile Squamous Cell Carcinoma Reveals Dynamics of Tumor Differentiation and Immune Microenvironment (Adv. Sci. 33/2025)

作者：Hongjian Song, Zhichao Tong, Guoxi Xie, Yaowei Li, Yubo Zhao, Fengpu Fan, Zongzheng Yang, Qing Shi, Qian Zhang, Feng Wen, Hongxue Meng, Haonan Li, Pengyu Guo, Da‐Yong Hou, Zhenwei Zhang, Zhihao Yin, Ziyi Liu, Jianwei Wang, Peng Zhang, Peng Dai, Changfu Li, Lichen Teng, Yangyang Xu, Dexin Ding, Tao Xu, Jianzhang Li, Yongsheng Chen, Yu Qiu, Xin Hu, Wentao Liu, Liang Wu, Roman Nawroth, Guibo Li, Hang Su, Ziqing Deng, Ziqi Wang, Di Wang, Wanhai Xu · 发表于：Advanced Science · 年份：2025 · DOI：10.1002/advs.71432 · 被引用次数：2 · 研究领域：Genital Health and Disease、Cancer Immunotherapy and Biomarkers

Penile Squamous Cell Carcinoma The image illustrates a spatially resolved atlas of penile epithelial differentiation, revealing how tumor cells in penile squamous cell carcinoma (PSCC) mimic the developmental trajectory of normal epithelium. In article number 2500216, Wanhai Xu and co-workers identify the Tum_1 subtype, defined by basal stem-like features and elevated invasive potential.