Multi-center investigation of cardiac diffusion tensor imaging in healthy volunteers by the Society of Cardiovascular Magnetic Resonance Cardiac Diffusion Special Interest Group NETwork (SIGNET)

作者：Irvin Teh, Kévin Moulin, Pedro Ferreira, Julie Absil, Maryam Afzali, Peter Agger, Behnaz Akbari, Anthony H. Aletras, Satoru Aono, Charles Benton, Suryava Bhattacharya, Pierre Croisille, Yves De Bruecker, Erica Dall’Armellina, Daniel B. Ennis, Carl Glessgen, Anna Glińska, Sandra Haltmeier, Ariel Hannum, Erik Hedström, Tawfik Hussein, Sarah Jones, George Joy, Karen Kettless, Won Yong Kim, Sebastian Kozerke, Julie Magat, Raja Muthupillai, Reza Nezafat, Sònia Nielles‐Vallespin, John N. Oshinski, Valéry Ozenne, Dudley J. Pennell, Roderick Pettigrew, Iain Pierce, Betty Raman, Agnieszka Sabisz, Jürgen E. Schneider, Janet C. Sherman, Abhishek Shetye, Rolf Symons, Philippe Thoma, Thomas A. Treibel, Satonori Tsuneta, Jean‐Paul Vallée, Niels Vejlstrup, Magalie Viallon, Christopher Nguyen, Andrew D. Scott, Christian T. Stoeck · 发表于：Journal of Cardiovascular Magnetic Resonance · 年份：2025 · DOI：10.1016/j.jocmr.2025.101948 · 被引用次数：2 · 研究领域：Advanced Neuroimaging Techniques and Applications、MRI in cancer diagnosis、Functional Brain Connectivity Studies

BACKGROUND: Cardiac diffusion tensor imaging (cDTI) is an emerging technique for microstructural characterization of the heart and has shown clinical potential in a range of cardiomyopathies. However, there is substantial variation reported for in vivo cDTI results across the literature, and sensitivity of cDTI to differences in imaging sites, scanners, acquisition protocols, and post-processing methods remains incompletely understood. METHODS: SIGNET is a prospective multi-center, observational study in traveling and non-traveling healthy volunteers. The study was initiated by the executive board of the Society of Cardiovascular Magnetic Resonance (SCMR) Cardiac Diffusion Special Interest Group (SIG) as a follow-up to a previous multi-center study on phantom validation of cardiac DTI and a recently published SCMR consensus statement on cardiac diffusion MRI. The study has been developed by the Project Management Committee in consultation with the SCMR cardiac diffusion SIG, which includes international experts in cardiac diffusion MRI. To date, more than 20 international institutions have engaged with the study, including sites that are new to cardiac DTI, making this the largest collaborative effort in the field. DISCUSSION: SIGNET will provide important information about the key sources of variation in cardiac DTI. This will help rationalize strategies for addressing and minimizing such variation. Harmonization of protocols in this and future studies will underpin efforts ...