Volatile pyrethroid spatial repellents for preventing mosquito bites: a systematic review and meta-analysis

作者：Ingrid Chen, Sarah Miller, Daniel Msellemu, Aidi Galus Lugenge, Johnson Kyeba Swai, Nicole L. Achee, Marta Andrés, Christopher S. Bibbs, Theeraphap Chareonviriyaphap, J. D. Charlwood, Gregor J. Devine, Noel M. Elman, Ulrike Fillinger, Carmen Flores-Mendoza, Seth Gibson, Nicodem J. Govella, Steven Gowelo, Sebastian Horstmann, Hitoshi Kawada, Daniel L. Kline, Aaron Lloyd, Neil F. Lobo, Marta F. Maia, Arnold S. Mmbando, Mara Moreno-Gómez, Amy C. Morrison, Winifrida P. Mponzi, Emmanuel P. Mwanga, Margaret M. Njoroge, Sheila B. Ogoma, Fredros O. Okumu, Mercy Opiyo, Welbeck A. Oumbouke, John Paliga, Arissara Pongsiri, Alongkot Ponlawat, Manop Saeaung, Ferdinand V. Salazar, Onyango P. Sangoro, Jennifer C. Stevenson, Chutipong Sukkanon, Din Syafruddin, Mgeni M. Tambwe, Julie-Anne A. Tangena, Élodie A. Vajda, Gonzalo M. Vazquez‐Prokopec, Joseph Wagman, Chanly Yan, Isabel Elaine Allen, Sarah Moore · 发表于：EBioMedicine · 年份：2025 · DOI：10.1016/j.ebiom.2025.105891 · 被引用次数：7 · 研究领域：Insect Pest Control Strategies、Mosquito-borne diseases and control、Malaria Research and Control

BACKGROUND: Volatile pyrethroid spatial repellents (VPSRs) can prevent mosquito-borne diseases including malaria and dengue fever, but the use of varied evaluation methods has resulted in a lack of clarity regarding their protective efficacy (PE) against contact with mosquitoes. This systematic review and meta-analysis consolidates the entomological evidence base on the PE of VPSRs against Anopheles, Aedes, and Culex mosquitoes and different test methods used. METHODS: We identified studies completed between January 2000 and September 2023 by searching through databases, conference abstracts, and personal correspondences. Included studies were semi-field or field studies that measured the PE of VPSRs using human landing catch (HLC) of mosquito landings on human legs and/or mosquito trap density, the number of mosquitoes captured using traps per set time period, compared to control groups. The systematic review summarised study-level data using a generalised linear mixed model with random effects. The meta-analysis pooled individual mosquito-level data and weather data on temperature, humidity, and wind from satellites, analysing PE subgrouped by product format, active ingredient, mosquito capture method used, mosquito species, and indoor vs outdoor setting. Risk of bias was assessed using a SYRCLE tool adapted for mosquito studies. Additional studies published from October 2023 to July 2025 were summarised. PROSPERO registration: CRD42021268852. FINDINGS: 58 eligible publicat...