Predicting long-term neurodevelopmental outcomes for children born very preterm: a systematic review

作者：Alice Burnett, Samuel B. Axford, Abdulbasit Seid, Peter J. Anderson, Jamie L. Waterland, Courtney P. Gilchrist, Joy E. Olsen, Ngoc Huy Nguyen, Alicia J. Spittle, Lex W. Doyle, Jeanie L.Y. Cheong · 发表于：Archives of Disease in Childhood Fetal & Neonatal · 年份：2025 · DOI：10.1136/archdischild-2025-328891 · 被引用次数：6 · 研究领域：Infant Development and Preterm Care、Neonatal Respiratory Health Research、Neonatal and fetal brain pathology

CONTEXT: Children born very preterm (<32 weeks' gestation) have increased risk of neurodevelopmental difficulties compared with those born at term. While various neonatal exposures have been linked with later developmental challenges, identifying those at risk of difficulties later in childhood remains a challenge but is essential for targeting early intervention and counselling families. OBJECTIVE: To systematically review and synthesise the evidence regarding early medical and environmental factors for neurodevelopmental impairment, cognitive, motor and behavioural outcomes for children born very preterm. DESIGN: Ovid MEDLINE, Embase and PubMed were searched for articles between 1 January 1990 and 29 April 2024 reporting on a representative, prospective geographical, network-based or multisite cohorts of children born <32 weeks' gestation. MAIN OUTCOME MEASURES: Neurodevelopmental impairment, cognitive, motor and emotional-behavioural functioning in children aged 36 months to 18 years. Data were extracted and reported descriptively due to heterogeneity in study measures. RESULTS: From 18 012 records, 29 studies from 16 cohorts were included. Brain injury, bronchopulmonary dysplasia, male sex and lower socioeconomic status were the most consistent predictors of neurodevelopmental impairment, IQ, working memory, cerebral palsy, fine motor skills and some behavioural measures. Emotional problems were generally not associated with neonatal variables investigated to date. CONCLU...