The Relationship Between C‐Reactive Protein–Triacylglycerol–Glucose Index and All‐Cause Mortality in Patients With Cardiovascular Disease: A Retrospective Cohort Study and Development of a Machine Learning Prediction Model

作者：Wenlong Ding, Fachao Shi, Zheng Wang, Long Wang, Chi-Hui Fang · 发表于：Cardiovascular Therapeutics · 年份：2025 · DOI：10.1155/cdr/6914985 · 被引用次数：3 · 研究领域：Liver Disease Diagnosis and Treatment、Adipokines, Inflammation, and Metabolic Diseases、Diabetes, Cardiovascular Risks, and Lipoproteins

Objective: The CTI is increasingly recognized as a new marker for assessing inflammation and insulin resistance. However, the relationship between CTI and all‐cause mortality risk in patients with CVD remains unclear. Methods: We analyzed data from the NHANES from 1999 to 2010. The correlation between CTI and all‐cause mortality risk in CVD patients was examined using Cox regression analysis. Nonlinear relationships between CTI and all‐cause mortality risk were explored through restricted cubic splines and Cox proportional hazards regression. We employed six ML models, including RF, LightGBM, DT, XGBoost, LR, and KNN, to predict all‐cause mortality risk in CVD patients based on CTI and SHAP for interpretability. Results: A total of 1429 CVD patients were included, with 849 all‐cause deaths recorded during the follow‐up period. After adjusting for potential confounding factors, the highest quartile of CTI (Q4) significantly increased the risk of all‐cause mortality compared to the lowest quartile (Q1) (HR = 1.38, 95% CI: 1.04–1.84, p = 0.03). Restricted cubic splines demonstrated a nonlinear relationship between CTI and all‐cause mortality risk in CVD patients. Among the machine learning models, the LightGBM model exhibited the best predictive performance, with an ROC of 0.967, accuracy of 0.909, sensitivity of 0.906, specificity of 0.914, F 1 score of 0.922, recall of 0.906, and PR of 0.979. SHAP analysis identified age, BU, and CTI as the primary predictive factors, with CTI...