TyG Index and Related Indices Predicting Hypertension: Mediation by Neutrophil-to-Lymphocyte Ratio in Multiple Chinese Cohorts

作者：Mengwen Sun, Yuanyuan Huang, Xingqiang Lü, Jinkai Qiu, Yuxuan Lin, Yan Huang, Xiaofeng Zheng, Weihong Qiu, Shanshan Du, Weimin Ye, Heng‐Gui Chen · 发表于：Nutrients · 年份：2025 · DOI：10.3390/nu17172859 · 被引用次数：4 · 研究领域：Adipokines, Inflammation, and Metabolic Diseases、Blood Pressure and Hypertension Studies、Nutritional Studies and Diet

Background: Hypertension remains a leading cause of cardiovascular morbidity and mortality globally, and insulin resistance (IR) and systemic inflammation are implicated in the pathogenesis of hypertension. Limited evidence exists on the predictive role of the triglyceride-glucose (TyG) index and its related indices (TyG-WHtR and TyG-WC) for hypertension. This study aimed to investigate these associations across multiple Chinese cohorts. Methods: Data from 31,224 participants (Fuqing, CHNS, CHARLS) were analyzed. TyG indices were calculated using fasting triglycerides, glucose, and anthropometrics. Hypertension was defined as SBP/DBP ≥ 140/90 mmHg, or physician diagnosis, or antihypertensive treatment. Logistic/Cox regression models were used to examine associations, adjusting for demographics, lifestyle, and metabolic factors. Mediation analysis quantified the role of neutrophil-to-lymphocyte ratio (NLR) in mediating the TyG–hypertension relationship. Results: Elevated TyG index and its obesity-adjusted variants consistently predicted incident hypertension across cohorts (all p < 0.001). Each 1-unit TyG increase was associated with 9–36% higher odds of hypertension in Fuqing (OR = 1.09–1.36). NLR mediated 20.4–29.4% of these associations (p < 0.001). Subgroup analyses revealed effect modifications by age, sex, and residence. Sensitivity analyses confirmed robustness when redefining hypertension thresholds (ACC/AHA criteria). Conclusions: TyG index and its related indic...