A brain-wide map of neural activity during complex behaviour

作者：Leenoy Meshulam, Dora E. Angelaki, Julius Benson, Isaiah McRoberts, Jean‐Paul Noel, Jaime Arlandis, Niccolò Bonacchi, Kcénia Bougrova, Joana Catarino, Fanny Cazettes, Davide Crombie, Eric DeWitt, Laura Freitas-Silva, Inês C. Laranjeira, Zachary F. Mainen, Guido T. Meijer, Pranav Rai, Georg Raiser, Florian Rau, Michael Schartner, Olivier Winter, Anne E Urai, Valeria Aguillon-Rodriguez, Cristian Soitu, Anthony M. Zador, Christopher Krasniak, Yang Dan, Fei Hu, Brandon Benson, Surya Ganguli, Luigi Acerbi, Gaëlle Chapuis, Charles Findling, Berk Gerçek, Felix Huber, Alexandre Pouget, Hailey Barrell, Dan Birman, Kim Miller, Kai Nylund, Noam Roth, Nicholas A. Steinmetz, Matthew G. Tucker, Kenneth C. C. Yang, Ila Fiete, Ari Liu, Rylan Schaeffer, Anne K. Churchland, M. Felicia Davatolhagh, Anup Khanal, Maxwell Melin, Masayoshi Murakami, Sophie Denève, Ivan Gordeliy, Mandana Ahmadi, Jaweria Amjad, Naoki Hiratani, Sanjukta Krishnagopal, Peter E. Latham, Alberto Pezzotta, Zekai Xu, Kush Banga, Jai Bhagat, Mayo Faulkner, Kenneth D. Harris, Michael Krumin, Samuel Picard, Carolina Quadrado, Cyrille Rossant, Miles J. Wells, Lauren E. Wool, Matteo Carandini, Agnès Landemard, Karolina Socha, Sebastian A. Bruijns, Peter Dayan, Julia M. Huntenburg, Debottam Kundu, Farideh Oloomi, Charline Tessereau, Zoe C. Ashwood, Tatiana A. Engel, Robert N. Fetcho, Laura M. Haetzel, Christopher Langdon, Brenna McMannon, Zeinab Mohammadi, Alejandro Pan-Vazquez, Jonathan W. Pillow, Nicholas Roy, Yan-Liang Shi, Ilana B. Witten, Robert A. A. Campbell, Naureen Ghani, Sonja B. Hofer, Hernando Martinez-Vergara, Nathaniel J Miska, Thomas D. Mrsic‐Flogel, Steven J. West, Yaxuan Yang, Karel Svoboda, Marsa Taheri, Michael Häusser, Petrina Lau, Amalia Makri-Cottington, Sabrina Perrenoud, Larry Abbot, H Bayer, Julien Boussard, E. Kelly Buchanan, Michele Fabbri, Cole Hurwitz, Christopher Langfield, Hyun Dong Lee, Catalin Mitelut, Liam Paninski, Kamron Saniee, Erdem Varol, Shuqi Wang, Matthew R Whiteway, Charles Windolf, Yu Han, Yizi Zhang, Dora E. Angelaki, Brandon Benson, Julius Benson, Daniel Birman, Niccolò Bonacchi, Kcénia Bougrova, Sebastian A. Bruijns, Matteo Carandini, Joana Catarino, Gaëlle Chapuis, Anne K. Churchland, Yang Dan, M. Felicia Davatolhagh, Peter Dayan, Eric DeWitt, Tatiana A. Engel, Michele Fabbri, Mayo Faulkner, Ila Fiete, Charles Findling, Laura Freitas-Silva, Berk Gerçek, Kenneth D. Harris, Michael Häusser, Sonja B. Hofer, Fei Hu, Félix Hubert, Julia M. Huntenburg, Anup Khanal, Christopher Krasniak, Christopher Langdon, Christopher Langfield, Petrina Lau, Zachary F. Mainen, Guido T. Meijer, Nathaniel J Miska, Thomas D. Mrsic‐Flogel, Jean‐Paul Noel, Kai Nylund, Alejandro Pan-Vazquez, Liam Paninski, Alexandre Pouget, Cyrille Rossant, Noam Roth, Rylan Schaeffer, Michael Schartner, Yan-Liang Shi, Karolina Socha, Nicholas A. Steinmetz, Karel Svoboda, Anne E Urai, Miles J. Wells, Steven J. West, Matthew R Whiteway, Olivier Winter, Ilana B. Witten · 发表于：Nature · 年份：2025 · DOI：10.1038/s41586-025-09235-0 · 被引用次数：89 · 研究领域：Neural dynamics and brain function、Neuroscience and Neuropharmacology Research、Memory and Neural Mechanisms

. It is difficult to meet this challenge if different laboratories apply different analyses to different recordings in different regions during different behaviours. Here we report a comprehensive set of recordings from 621,733 neurons recorded with 699 Neuropixels probes across 139 mice in 12 laboratories. The data were obtained from mice performing a decision-making task with sensory, motor and cognitive components. The probes covered 279 brain areas in the left forebrain and midbrain and the right hindbrain and cerebellum. We provide an initial appraisal of this brain-wide map and assess how neural activity encodes key task variables. Representations of visual stimuli transiently appeared in classical visual areas after stimulus onset and then spread to ramp-like activity in a collection of midbrain and hindbrain regions that also encoded choices. Neural responses correlated with impending motor action almost everywhere in the brain. Responses to reward delivery and consumption were also widespread. This publicly available dataset represents a resource for understanding how computations distributed across and within brain areas drive behaviour.