Electrochemical Sensors Based on Dirac Semimental NiTe2 in the Detection of SARS-CoV-2

作者：Jiangyue Bai, Yujiu Jiang, Shiqi Xu, Xiuxia Li, Yina Dong, Chunpan Zhang, Qinger Yao, Nan Cheng, Haizhen Gao, Yanbo Yang, Zhiwei Wang, Bingteng Xie, Peng Zhu, Shanshan Li, Junfeng Han · 发表于：Langmuir · 年份：2025 · DOI：10.1021/acs.langmuir.5c03027 · 被引用次数：1 · 研究领域：Advanced Thermoelectric Materials and Devices、MXene and MAX Phase Materials、2D Materials and Applications

In the present study, a topological semimetal NiTe 2 -based electrochemical biosensor was designed and fabricated, leveraging the material’s inherent topological surface state and conductive bulk properties. The NiTe 2 electrode was fabricated via mechanical exfoliation from a high-quality NiTe 2 single crystal. Owing to its robust layered structure and unique Dirac surface states, the topological semimetal NiTe 2 facilitates rapid electron transfer at the electrode surface, thereby enhancing the sensor’s performance. The developed biosensor showed a linear response range for DNA concentrations spanning from 10 –15 to 10 –7 M, with a detection limit as low as 10 –16 M. In contrast, its detection response toward RNA was more sensitive, covering a concentration range of 10 –18 to 10 –15 M. Furthermore, this sensor was employed for the detection of synthetic SARS-CoV-2 pseudovirus at a concentration of 1000 copies/mL. The results demonstrated that the sensor could effectively differentiate between negative and positive samples, exhibiting excellent sensitivity, specificity, and stability. Consequently, the NiTe 2 -based biosensor possesses significant potential for application in the clinical diagnosis of SARS-CoV-2 pathogens and other acute infectious diseases.