CRISPR/Cas9-Engineered Triple-Fusion Reporter Gene Imaging System for Monitoring Transplanted Neural Progenitor Cells in Ischemic Stroke

作者：Xiaoyi Li, Yan Zhong, Chentao Jin, Xiang Chen, Xingyue Cui, Yangyang Xu, Yang Fan, Fahuan Song, Peili Cen, La Dong, Kaiwu Yu, Qinggang He, Jing Wang, Shijun Hu, Xiao‐Yong Zhang, Cong Li, Mei Tian, Hong Zhang · 发表于：Radiology · 年份：2025 · DOI：10.1148/radiol.250305 · 被引用次数：6 · 研究领域：Neuroinflammation and Neurodegeneration Mechanisms、Extracellular vesicles in disease、Neuroscience and Neural Engineering

A clustered regularly interspaced short palindromic repeats/CRISPR-associated nuclease 9 (known as CRISPR/Cas9)–engineered triple-fusion reporter gene imaging system combined with a noninvasive agonistic micelle-based approach enabled in vivo monitoring of transplanted human neural progenitor cells in a rat model of ischemic stroke.