Nonlinear associations between the aggregate index of systemic inflammation and cardiovascular disease in adults: evidence from NHANES 2011–2020

作者：Run Wang, Ruoling Chen, Weijun Tao, Xiaobing Cheng · 发表于：BMC Public Health · 年份：2025 · DOI：10.1186/s12889-025-24320-9 · 被引用次数：12 · 研究领域：Inflammatory Biomarkers in Disease Prognosis、Adipokines, Inflammation, and Metabolic Diseases、Cardiac Health and Mental Health

BACKGROUND: Although the connection between inflammation and cardiovascular disease (CVD) is well-documented, the association involving the aggregate index of systemic inflammation (AISI)-a distinctive indicator derived from this formula (neutrophil count × monocyte count × platelet count)/lymphocyte count-has not been extensively explored. Addressing this research gap, our study leveraged the National Health and Nutrition Examination Survey (NHANES) database for investigating a correlation among AISI and CVD among adults in U.S. This investigation provides new insights into the inflammatory mechanisms underlying cardiovascular conditions and may have implications for preventive and therapeutic strategies in cardiovascular health. METHODS: Our study included 23,472 adults from the 2011-2020 NHANES database. The relationship between AISI and CVD was examined using weighted generalized linear models, subgroup analyses, and threshold effects to estimate effect sizes and saturation effects. Nonlinear relationships between the AISI and CVD were further elucidated through smoothed curve analyses. RESULTS: The prevalence of CVD increases with AISI(P < 0.001). Within weighted generalized linear models, individuals within Quartile 4 [OR = 1.27, 95%CI (1.00, 1.61)] exhibited a favorable correlation with CVD prevalence, in contrast to the figures observed during Quartile 1. Notably, this correlation was consistent across various subgroups, indicating its independence from factors such a...