Environment-wide association study of cardiovascular-kidney-metabolic syndrome based on NHANES 2013–2016

作者：Jianhua Ma, Pingan Li, Lixin Tao, Xinghua Yang, Yanxia Luo, Xiuhua Guo, Bo Gao · 发表于：Ecotoxicology and Environmental Safety · 年份：2025 · DOI：10.1016/j.ecoenv.2025.118993 · 被引用次数：5 · 研究领域：Health, Environment, Cognitive Aging、Metabolomics and Mass Spectrometry Studies、Effects and risks of endocrine disrupting chemicals

BACKGROUND: Environmental chemical exposure has emerged as an important risk factor for cardiometabolic and other chronic diseases. Cardiovascular-kidney-metabolic (CKM) syndrome conceptualizes the overlap of cardiovascular, kidney, and metabolic diseases as a systemic condition, providing a comprehensive framework for systematically identifying their risk factors. This study aimed to assess the associations between multiple environmental chemicals and CKM syndrome and to examine the potential mediating role of inflammation. METHODS: The analysis was based on NHANES data from the 2013-2016 period. An exposome-wide approach was applied to identify environmental chemicals associated with CKM syndrome. Restricted cubic splines (RCS) were used to examine potential nonlinear associations. To evaluate the joint associations of multiple exposures, both weighted quantile sum (WQS) regression and quantile-based g-computation (Qgcomp) were employed. Mediation analyses were performed to explore inflammation as a possible pathway. RESULTS: Six environmental chemicals were found to be associated with CKM syndrome, including metals (tin), volatile organic compound metabolites (VOCMs: n-A-S-(3-hydrxprpl-1-metl)-L-cys, n-ace-S-(3,4-dihidxybutl)-L-cys), polycyclic aromatic hydrocarbons (PAHs: 1-hydroxyphenanthrene, 2&3-hydroxyphenanthrene), and iodine. A U-shaped relationship was observed between barium, cobalt, strontium, thallium, nitrate, and 2&3-hydroxyphenanthrene and the risk of advance...