Plant-Derived Exosome-Like Nanovesicles: A Novel Strategy for Targeted Oral Therapy in Ulcerative Colitis

作者：Hang Ning, Xinyu Huang, Na Deng, Xueyuan Lin, Ling Zheng, Ying Zhu, Yin Xu · 发表于：International Journal of Nanomedicine · 年份：2025 · DOI：10.2147/ijn.s536056 · 被引用次数：18 · 研究领域：Extracellular vesicles in disease、Inflammasome and immune disorders、RNA Interference and Gene Delivery

Ulcerative colitis (UC) is a chronic inflammatory bowel disease, the incidence of which continues to rise globally, and existing therapeutic options are limited by low drug bioavailability and systemic side effects. In this study, we systematically investigated the challenges of the special gastrointestinal environment of UC patients for oral drug delivery, such as extreme pH, degradation by digestive enzymes, metabolism of intestinal flora and obstruction of the intestinal mucosal barrier, and summarized the potential of plant-derived Exosome-like Nanovesicles (PELNs) as a novel delivery system. PELNs are produced by plant cells and mainly consist of proteins, RNA, lipids and plant active molecules. Animal and cell experiments have shown that they can treat UC through the regulation of the intestinal bacterial flora, the inhibition of inflammatory pathways, and the promotion of mucosal repair, etc. On the other hand, their small particle size (30-500 nm), negative charge and lipid bilayer structure enable them to penetrate the intestinal mucus layer, tolerate extreme pH and enzymatic degradation, and adhere to intestinal epithelial cells through electrostatic interactions, thus possessing advantages such as low immunogenicity, high stability and natural targeting. Furthermore, the engineering modification of PELNs can significantly enhance targeting and therapeutic efficacy, such as surface modification or drug loading. Future research should focus on the systematic characte...