Synthesis of Novel 1,4‐Diazepane‐Spirooxindole Frameworks via Catalytic (6 + 1) Annulation of Diazooxindoles with Hexahydropyrimidines

作者：Xiaoai Liu, Song Gao, Chao Peng, Yu Xiong, Ye Guo, Ming Lang, Shiyong Peng · 发表于：Asian Journal of Organic Chemistry · 年份：2025 · DOI：10.1002/ajoc.202500587 · 被引用次数：3 · 研究领域：Cyclopropane Reaction Mechanisms、Asymmetric Synthesis and Catalysis、Catalytic C–H Functionalization Methods

Abstract Herein, we have developed a catalytic (6 + 1) annulation of diazooxindoles with hexahydropyrimidines under rhodium or copper catalysis. This strategy offers a general and efficient method for constructing pharmacologically relevant 1,4‐diazepane‐spirooxindole frameworks in moderate to excellent yields. Diverse synthetic transformations of the obtained products have also been achieved to obtain more complex and even drug‐like spirooxindoles, demonstrating the broad synthetic utility of this approach.