Bioactive Cyclodepsipeptides from Cocultured Mangrove-Derived Aspergillus sp. and Penicillium sp.

作者：Yu Wang, Guang-Ping Cao, Xin-Jian Qu, Yonghong Liu, Xiangxi Yi, Chenghai Gao, Meng Bai · 发表于：Journal of Natural Products · 年份：2025 · DOI：10.1021/acs.jnatprod.5c00752 · 被引用次数：2 · 研究领域：Microbial Natural Products and Biosynthesis、Antimicrobial Peptides and Activities、Marine Sponges and Natural Products

Three new arthrichitin derivatives I–K ( 1 – 3 ) and three known congeners ( 4 – 6 ) were isolated from a coculture of mangrove-derived fungi Aspergillus sp. and Penicillium sp. using 1 H NMR-guided fractionation. Their structures were determined by comprehensive spectroscopic analysis (1D/2D NMR, HRESIMS, ESI-MS/MS), Marfey’s analysis, DP4+ probability, and experimental/computed ECD comparison. All compounds were evaluated for antibacterial effects and cytotoxicity. Notably, compounds 1 and 5 showed weak cytotoxicity against MHCC-97H cells (IC 50 = 20.1 ± 0.9 and 25.8 ± 0.4 μM, respectively). Compound 4 exhibited potent anti-BPH activity (IC 50 = 0.36 ± 0.02 μM).