Mobile App–Based Intervention and Cardiovascular Risk Factors in Patients With Uncontrolled Type 2 Diabetes

作者：Peizhen Zhang, Dan Guo, Changqin Liu, Ning Chen, Jianfang Liu, Xuzhen Lei, Linjie Yang, Ya-Ting Liu, Li Xu, Junfeng Huang, Caiwen Du, Kai Wang, Wei Mo, Jia-Yang Lin, Chensihan Huang, Bing-Yan Xu, Xueyun Wei, D. Liu, Junlin Huang, Yan Huang, Yaoming Xue, Yanmei Zeng, Shiqun Liu, Zhimin Ma, Huijie Zhang · 发表于：JAMA Network Open · 年份：2025 · DOI：10.1001/jamanetworkopen.2025.29762 · 被引用次数：5 · 研究领域：Mobile Health and mHealth Applications、Diabetes Management and Education、Health Promotion and Cardiovascular Prevention

Importance: Controlling modifiable cardiovascular risk factors is important but underused for patients with type 2 diabetes (T2D). Mobile message-based intervention strategies could address this gap but lack evidence of benefit on multiple risk factors. Objective: To evaluate the effectiveness of a mobile message-based intervention in controlling cardiovascular risk factors in patients with T2D. Design, Setting, and Participants: In this randomized clinical trial, adults with uncontrolled T2D comorbid with cardiovascular disease (CVD) risk factors were recruited from 5 clinical centers in China. Data were collected from November 2018 to March 2022 and analyzed from January to June 2023. Intervention: Participants were randomized to receive either usual care or a mobile message-based intervention of 6 text messages per week from different modules designed to remind, encourage, and motivate them to participate in the behaviors needed for improving glycemic control and CVD risk factor management for 12 months. Main Outcomes and Measures: The primary outcome included mean changes in hemoglobin A1c (HbA1c), low-density lipoprotein cholesterol (LDL-C), and systolic blood pressure (SBP) levels across 12 months. The secondary outcomes included the percentage of participants with controlled HbA1c at 12 months. Data were analyzed using the intention-to-treat principle. Results: A total of 819 participants (552 men [67.4%]; mean [SD] age, 50.1 [11.9] years; mean [SD] HbA1c level, 10.2% ...