Noninvasive Biomarkers for Allograft Monitoring After Intestinal Transplantation: Continued Promise of a Novel Peptide, Reg3A

作者：Carolyn Smullin, Robert S. Venick, Elizabeth A. Marcus, Yvette Golaz, Scarlet Lee, Justin Centino, Yu Ling, Suzanne V. McDiarmid, Douglas G. Farmer · 发表于：Intestinal failure. · 年份：2025 · DOI：10.1016/j.intf.2025.100125 · 被引用次数：1 · 研究领域：Clinical Nutrition and Gastroenterology、Infant Nutrition and Health、Helicobacter pylori-related gastroenterology studies

Background: There is no reliable test to monitor for ITx rejection. Reg3A is an anti-inflammatory protein constitutively expressed in the intestine and upregulated by injurious stimuli. Prior studies have established Reg3A as biomarker in IBD and GI GVHD. Until recently, Reg3A has never been studied in ITx. In a prior retrospective cohort study, we found that secretory Reg3A levels were significantly increased during episodes of rejection. We sought to expand upon those results.