Early-life nutritional additives, household environment, and air pollution in relation to childhood food allergies: A multi-city mother–child study in China

作者：Chan Lu, Ying Jiang, Wen Deng, Mengju Lan, Lin Wang, Yeqing Tong, Zipeng Qiao, Wanxue Xu, Ting Li, Weiwei Liu, Faming Wang · 发表于：Environment International · 年份：2025 · DOI：10.1016/j.envint.2025.109774 · 被引用次数：6 · 研究领域：Food Allergy and Anaphylaxis Research、Health, Environment, Cognitive Aging、Effects and risks of endocrine disrupting chemicals

BACKGROUND: Nutritional supplements and environments have been linked with food allergy (FA), but little research has explored their interactions on children's FA. OBJECTIVES: To explore the associations between early-life nutritional supplements, household environmental factors (HEFs), and outdoor air pollutant (OAP) exposures, and their interactions on children's FAs. METHODS: We collected 20,730 surveyed questionnaires from five Chinese cities, covering data on individual characteristics, health outcomes, and HEFs. Multilevel logistic regression models were conducted to establish the impacts of early-life nutritional supplements, HEFs, and OAP exposures on children's FAs. RESULTS: exposure within the first trimester, while not consistently related with other pollutants in different models. Maternal and childhood intake of nutritional supplements mitigated adverse impacts of HEFs and OAP exposure on FA, while amplifying protective effects, indicating a nutrition-pollution interaction. CONCLUSIONS: Early-life nutritional supplements, HEFs, and OAP exposures separately and jointly influence children's FA. However, the possibility of false positives due to multiple testing cannot be excluded, which should be interpreted with caution pending replication.