Assessing the prognostic accuracy of the PSS, pSOFA, and SIRS for in-hospital mortality in children with suspected infection in non-ICU settings: a multicenter retrospective study

作者：Ruiying Liu, Xuanwen Ru, Zihao Yang, Tiewei Li, Junmei Yang, Yang Liu, Xiaoyu Cui, Jing Wu, Ruijie Yu, Zhan Ma, Baoyu Yuan, Feng Cheng, Suhong Huang, Caizhi Huang, Cong Zhang, Hongbing Chen, Xun Zhou, Xiao‐Wei Zhang, Jingran Wang, Xin Lv, Qian Zeng, Hong Zhu, Xuejun Shao, Feng Tang, Xuyang Gong, Ping Ling, Kun Chi, Guofeng Liu, Zhenwen Zhou, Xiaochun Liu, Qing Ye · 发表于：International Journal of Infectious Diseases · 年份：2025 · DOI：10.1016/j.ijid.2025.108044 · 被引用次数：10 · 研究领域：Sepsis Diagnosis and Treatment、Neonatal and Maternal Infections、Neonatal Respiratory Health Research

OBJECTIVES: To systematically compare the predictive accuracy of the Phoenix Sepsis Score (PSS), the Pediatric Sequential Organ Failure Assessment (pSOFA), and systemic inflammatory response syndrome (SIRS) in assessing in-hospital mortality risk among pediatric sepsis patients in non-intensive care unit (non-ICU) wards, thereby providing evidence-based support for clinical risk stratification. DESIGN: This study employed a multicenter retrospective cohort design, enrolling non-ICU pediatric patients with suspected infections (excluding preterm infants and neonates hospitalized immediately after birth), to construct an overall cohort and a neonatology subgroup cohort. Clinical parameters were collected through a data acquisition system, with parallel calculations of PSS, pSOFA, and SIRS scores. The primary endpoint was in-hospital mortality. Receiver operating characteristic (ROC) curves were constructed via R language version 4.3.1, and the discriminatory performance of each scoring system was evaluated via the area under the ROC curve (AUROC). RESULTS: From January 2023 to September 2024, 965 non-ICU pediatric patients with infections were enrolled from 13 medical centers (overall cohort mortality: 1.1%, 11/965; neonatology cohort: 193 cases, mortality: 4.1%, 8/193). In the overall cohort, all 11 patients experienced deterioration on the ward and were subsequently transferred to the pediatric intensive care unit (PICU) in accordance with each hospital's protocol; eight of t...