Exosome-like nanovesicles from Dunaliella salina efficient sequential Co-delivery of anti-PDL1 and miR-375 for enhancing gene/immune therapy

作者：Zhaoyi Wei, Mengxi Zhu, Shan Li, Junling An, Yiwen Liu, Shuying Feng, Tingting Yang, Shegan Gao, Gaofeng Liang · 发表于：Non-coding RNA Research · 年份：2025 · DOI：10.1016/j.ncrna.2025.08.007 · 被引用次数：4 · 研究领域：Extracellular vesicles in disease、14-3-3 protein interactions、Nanoplatforms for cancer theranostics

Background: Esophageal cancer is one of the common malignant tumors of digestive system. Despite many advances in the treatment of esophageal cancer, many challenges remain. As an endogenous extracellular vesicle, exosomes are increasingly presenting their immense potential in drug delivery. However, it remains a bottleneck to obtain a large quantity of uniform, stable, and multi-component controllable exosomes with low cost and time. Methods: . Results: results showed that cRGD-DENV-aPDL1/miR375 significantly inhibited tumor growth and affected the proliferation, migration and invasion of esophageal cancer cells by regulating YWHAZ. Conclusions: exosome-like nanovesicle carrier delivery system in cancer therapy and can provide a very promising platform for the rapid and large-scale generation of functionalized exosome-like nanovesicles.