Treatment outcomes and associated influencing factors among elderly patients with rifampicin-resistant tuberculosis: a multicenter, retrospective, cohort study in China

作者：Huicong Liu, Li‐Ping Zou, Jiajia Yu, Qingdong Zhu, Song Yang, Wanli Kang, Jiaojie Ma, Qing Chen, Zhengyu Shi, Xianzhen Tang, Liang Li, Peijun Tang, Qing Pan, Chunhui Guo, Juan Du, Zhanlin Chang, Zhouli Guo, Guihui Wu, Shenjie Tang · 发表于：BMC Infectious Diseases · 年份：2025 · DOI：10.1186/s12879-025-11491-4 · 被引用次数：3 · 研究领域：Tuberculosis Research and Epidemiology、Infectious Diseases and Tuberculosis、Diagnosis and treatment of tuberculosis

BACKGROUND: Rifampicin-resistant tuberculosis (RR-TB) remains a significant global public health concern. The elderly population is not only at high risk and among the primary victims of RR-TB but also plays a crucial role in the transmission chain of RR-TB. Their biological particularities, treatment complexities, and social vulnerabilities collectively present substantial challenges to global tuberculosis control. This study aimed to evaluate treatment outcomes and identify predictors of unfavorable outcomes among elderly patients with RR-TB in China. METHODS: A multicenter retrospective cohort study was conducted, including 248 elderly RR-TB patients treated across eight tertiary hospitals in China from May 2018 to April 2020. Multivariate logistic regression and Propensity Score Matching (PSM) analyses were performed to identify factors associated with unfavorable outcomes. Statistical analyses were performed using SPSS. RESULTS: Among 248 patients, 65.7% (163/248) achieved treatment success (cured or completed treatment), while 34.3% (85/248) experienced unfavorable outcomes, including treatment failure (10.5%), death (2.4%), loss to follow-up (15.7%), and non-evaluation (5.6%). Adverse events (AEs) were reported in 56.0% (139/248) of patients, among which anemia was the most common (25.8%). And the use of bedaquiline and linezolid was significantly associated with the occurrence of QT interval prolongation and optic neuritis (p < 0.05). Multivariate analysis revealed th...