Global, regional, and national temporal trend in burden of chronic respiratory diseases from 1990 to 2021: Findings from the Global Burden of Disease Study 2021

作者：Zifeng Ma, Bing Li, Yu Qian, Shuyi Mu, Yu Wang, Jie Cui, Lei Qiu, Jinxin Zheng, Yan Li, Fuqiang Wen, Zhenhui Lu · 发表于：Chinese Medical Journal · 年份：2025 · DOI：10.1097/cm9.0000000000003670 · 被引用次数：7 · 研究领域：Sarcoidosis and Beryllium Toxicity Research、Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis、Chronic Obstructive Pulmonary Disease (COPD) Research

BACKGROUND: Chronic respiratory diseases (CRDs), including chronic obstructive pulmonary disease (COPD), asthma, pneumoconiosis, interstitial lung disease (ILD), and pulmonary sarcoidosis, continue to pose a significant global health challenge. This study aims to assess the global, regional, and national burden of CRDs from 1990 to 2021, using data from the Global Burden of Disease Study (GBD) 2021 to identify key trends and advise future public health strategies. METHODS: Data from the GBD 2021 were used to estimate the incidence, prevalence, mortality, and disability-adjusted life years (DALYs) of CRDs and their subtypes across 21 global regions and 204 countries and regions from 1990 to 2021. The temporal trend was analyzed and the relationship between CRD burden and socio-demographic index (SDI) was examined using a smoothing spline model. A Bayesian age-period-cohort model was used to project the burden of CRDs to 2035. RESULTS: The global age-standardized rate (ASR) of incidence, prevalence, mortality, and DALY for CRDs declined by 24%, 27%, 37%, and 38%, respectively, from 1990 to 2021. However, the absolute burden of CRDs continues to grow due to population aging and demographic changes. Asthma accounts for most of the CRD-related incidence and prevalence, particularly in high-SDI regions, while COPD accounts for most CRD-related deaths and DALYs, especially in low-middle SDI regions. The ASR of incidence, prevalence, mortality, and DALYs for ILD and pulmonary sarcoid...