Preparation of superparamagnetic iron oxide nanoparticles conjugated hollow gold nanospheres for MR/CT dual-mode imaging and synergistic photothermal-chemotherapy of cancer

作者：Zhen Jin, Linyan Xie, Ke Bao, Jiawei Xu, Lin Feng, Yi Guo, Mao Wang, Dongmei Zheng, Lai-Bo Song, Wenlong Zhang, Wu Ren · 发表于：Journal of Science Advanced Materials and Devices · 年份：2025 · DOI：10.1016/j.jsamd.2025.100977 · 被引用次数：2 · 研究领域：Nanoparticle-Based Drug Delivery、Nanoplatforms for cancer theranostics、Photoacoustic and Ultrasonic Imaging

The development of multifunctional nanotheranostics that are safe, stimuli responsive for controlled drug release and possess the capability of precise imaging guided multi-modal synergistic therapy is of great significance for anti-cancer treatment. In this study, a multifunctional DOX-HSP nanocomposite was prepared by conjugating superparamagnetic iron oxide (SPIO) nanoparticles on the surface of DOX loaded hollow gold nanospheres (HGNs) and PEG modification for computed tomography (CT)/magnetic resonance (MR) dual-mode imaging and synergistic photothermal-chemotherapy. The prepared DOX-HSP demonstrated favorable biocompatibility, high drug loading capacity and considerable MR/CT image contrast agent capability. Moreover, on-demand controlled drug release could be achieved by well preventing the premature drug release with the blocking effect of conjugated SPIO nanoparticles in normal physiological environment and triggering drug release with NIR exposure in acidic environment. Furthermore, the in vitro cell experiment revealed that the anti-tumor effect could be significantly enhanced via synergistic photothermal-chemotherapy. Therefore, we believe that the prepared DOX-HSP nanocomposite could provide great potential values for biomedical area, including MR/CT imaging and synergistic cancer photothermal-chemotherapy.