Outcomes in Military Blood Donors at Joint Base San Antonio With Reactive Trypanosoma cruzi Antibody Screening Results

作者：Michael J Wells, Brian Casleton, Melita Gella, Glorimar Z. Rivera, Megan L Phelps, Theresa Casey, Angela Osuna, Guhung Jung, Erin L Winkler, Heather C. Yun, Joseph E Marcus · 发表于：Open Forum Infectious Diseases · 年份：2025 · DOI：10.1093/ofid/ofaf522 · 被引用次数：1 · 研究领域：Trypanosoma species research and implications、Research on Leishmaniasis Studies、Science and Education Research

Abstract Background All blood donors in the United States are universally screened once for Trypanosoma cruzi antibodies to prevent transfusion-transmitted Chagas disease, but military donors are screened with every donation. Previous studies of military blood donors demonstrated that reactive T cruzi antibodies were a common reason for postdonation deferral, but follow-up is unclear. This study evaluated the diagnostic evaluation of blood donors with reactive T cruzi screening results. Methods Medical records of all blood donors at the Armed Services Blood Bank Center at Joint Base San Antonio–Lackland with reactive screening results for T cruzi antibodies between January 2017 to December 2022 were evaluated after chemiluminescent immunoassay or chemiluminescent microparticle immunoassay screening and enzyme strip assay supplementary testing. Records were assessed to determine the diagnostic evaluation and final diagnosis of each case following initial reactive screening results. Results Of 89,459 blood donors during the study period, 49 (0.055%) screened reactive for T cruzi antibodies on initial blood donation. Of those, 4 (8%) had positive and 18 (36%) had indeterminate supplementary test results. No donors met criteria for Chagas disease on clinical diagnostic testing. Of the 8 with repeated screening testing ordered in the weeks after their original reactive result, only 1 (13%) had a repeated reactive screening test result but negative confirmatory serologic results. C...